Lignans with NADPH Oxidase 2 (NOX2)-inhibitory Activity from the Fruits ofSchisandra chinensis

NADPH Oxidase NOX2 Mediates Rapid

The Role of the NADPH Oxidase NOX2 in Prion Pathogenesis

Prion infections cause neurodegeneration, which often goes along with oxidative stress. However, the cellular source of reactive oxygen species (ROS) and their pathogenetic significance are unclear. Here we analyzed the contribution of NOX2, a prominent NADPH oxidase, to prion diseases. We found that NOX2 is markedly upregulated in microglia within affected brain regions of patients with Creutz...

Lignans from Leaves of Juniperus Chinensis

Umbelliferone, 13 lignans and an unusual compound 2-(3,4-methylenedioxyphenyl)propane-1,3-diol, were isolated from the leaves of Juniperus chinensis. The lignans include meso-secoisolariciresinol, 3,4-methylenedioxy-3’,4’dimethoxylignan-9’,9-olide, hibalactone, isohibalactone, 7-oxohinokinin, 7-hydroxyhinokinin, 7-acetyloxyhinokinin, (+ )-xanthoxylol, dihydrodehydrodiconiferyl alcohol, 3-methox...

NOX2β: A Novel Splice Variant of NOX2 That Regulates NADPH Oxidase Activity in Macrophages

Nox2 oxidase is one isoform in a family of seven NADPH oxidases that generate reactive oxygen species (ROS) and thereby contribute to physiological and pathological processes including host defense, redox signaling and oxidative tissue damage. While alternative mRNA splicing has been shown to influence the activity of several Nox-family proteins, functionally relevant splice variants of Nox2 ha...

Signalling mechanisms underlying doxorubicin and Nox2 NADPH oxidase‐induced cardiomyopathy: involvement of mitofusin‐2

BACKGROUND AND PURPOSE The anthracycline doxorubicin (DOX), although successful as a first-line cancer treatment, induces cardiotoxicity linked with increased production of myocardial ROS, with Nox2 NADPH oxidase-derived superoxide reported to play a key role. The aim of this study was to identify novel mechanisms underlying development of cardiac remodelling/dysfunction further to DOX-stimulat...